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Staphylococcus aureus  belongs to one of the most common bacteria causing healthcare and community associated infections in China, but their molecular characterization has not been well studied. From May 2011 to June 2012, a total of 322 non-duplicate  S. aureus  isolates were consecutively collected from seven tertiary care hospitals in seven cities with distinct geographical locations in China, including 171 methicillin sensitive  S. aureus  (MSSA) and 151 MRSA isolates. All isolates were characterized by  spa  typing. The presence of virulence genes was tested by PCR. MRSA were further characterized by SCC mec  typing. Seventy four and 16  spa  types were identified among 168 MSSA and 150 MRSA, respectively. One  spa  type t030 accounted for 80.1% of all MRSA isolates, which was higher than previously reported, while  spa -t037 accounted for only 4.0% of all MRSA isolates. The first six  spa  types (t309, t189, t034, t377, t078 and t091) accounted for about one third of all MSSA isolates. 121 of 151 MRSA isolates (80.1%) were identified as SCC mec  type III.  pvl  gene was found in 32 MSSA (18.7%) and 5 MRSA (3.3%) isolates, with ST22-MSSA-t309 as the most commonly identified strain. Compared with non-epidemic MRSA clones, epidemic MRSA clones (corresponding to ST239) exhibited a lower susceptibility to rifampin, ciprofloxacin, gentamicin and trimethoprim-sulfamethoxazole, a higher prevalence of  sea  gene and a lower prevalence of  seb ,  sec ,  seg ,  sei  and  tst  genes. The increasing prevalence of multidrug resistant  spa -t030 MRSA represents a major public health problem in China.

Characterization of Staphylococcus aureus from Distinct Geographic Locations in China: An Increasing Prevalence of spa-t030 and SCCmec Type III