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Background  The relationship between  Fas  -1377 G/A polymorphism and cancer susceptibility has been implicated in accumulating data. However, the data presented inconsistent results. This study was devised to investigate the association of  Fas  -1377 G/A polymorphism and cancer susceptibility in a large number of participants.    Methods  The databases of PubMed, Embase, and Web of Science were searched and a total of 27 case-control studies including 13,355 cases and 16,078 controls were included in this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model. Statistical analyses were performed by using Stata software.    Results  The results suggested that  Fas  -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06–1.27,  P   heterogeneity   = 0.381; recessive model: OR, 1.19, 95%CI = 1.10–1.29,  P   heterogeneity   = 0.137). In the subgroup analysis by cancer type, significantly increased risk was observed in breast cancer (additive model: OR, 1.24, 95%CI = 1.04–1.58,  P   heterogeneity   = 0.614; recessive model: OR, 1.24, 95%CI = 1.02–1.51,  P   heterogeneity   = 0.349) and lung cancer (recessive model: OR, 1.25, 95%CI = 1.04–1.49,  P   heterogeneity   = 0.090). Similarly, elevated cancer risk associated with  Fas  -1377 G/A polymorphism was revealed in Asians.    Conclusions  The combined results suggest that  Fas  -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner.

Association of Fas -1377 G/A Polymorphism with Susceptibility to Cancer