English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Dendritic cells (DCs) can be sub-divided into various subsets that play specialized roles in priming of adaptive immune responses. Atherosclerosis is regarded as a chronic inflammatory disease of the vessel wall and DCs can be found in non-inflamed and diseased arteries. We here performed a systematic analyses of DCs subsets during atherogenesis. Our data indicate that distinct DC subsets can be localized in the vessel wall. In C57BL/6 and low density lipoprotein receptor-deficient ( Ldlr   −/− ) mice, CD11c +  MHCII +  DCs could be discriminated into CD103 −  CD11b + F4/80 + , CD11b + F4/80 −  and CD11b − F4/80 −  DCs and CD103 +  CD11b − F4/80 −  DCs. Except for CD103 −  CD11b −  F4/80 −  DCs, these subsets expanded in high fat diet-fed  Ldlr   −/−  mice. Signal-regulatory protein (Sirp)-α was detected on aortic macrophages, CD11b +  DCs, and partially on CD103 −  CD11b −  F4/80 −  but not on CD103 +  DCs. Notably, in FMS-like tyrosine kinase 3-ligand-deficient ( Flt3l   −/− ) mice, a specific loss of CD103 +  DCs but also CD103 −  CD11b +  F4/80 −  DCs was evidenced. Aortic CD103 +  and CD11b +  F4/80 −  CD103 −  DCs may thus belong to conventional rather than monocyte-derived DCs, given their dependence on Flt3L-signalling. CD64, postulated to distinguish macrophages from DCs, could not be detected on DC subsets under physiological conditions, but appeared in a fraction of CD103 −  CD11b +  F4/80 −  and CD11b +  F4/80 +  cells in atherosclerotic  Ldlr   −/−  mice. The emergence of CD64 expression in atherosclerosis may indicate that CD11b +  F4/80 −  DCs similar to CD11b +  F4/80 +  DCs are at least in part derived from immigrated monocytes during atherosclerotic lesion formation. Our data advance our knowledge about the presence of distinct DC subsets and their accumulation characteristics in atherosclerosis, and may help to assist in future studies aiming at specific DC-based therapeutic strategies for the treatment of chronic vascular inflammation.

Dendritic Cell Subset Distributions in the Aorta in Healthy and Atherosclerotic Mice