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Poly(A)-binding proteins are highly conserved among eukaryotes and regulate stability of mRNA and translation. Among  C. elegans  homologues,  pab-1  mutants showed defects in germline mitotic proliferation. Unlike  pab-1  mutants,  pab-1  RNAi at every larval stage caused arrest of germline development at the following stage, indicating that  pab-1  is required for the entire postembryonic germline development. This idea is supported by the observations that the mRNA level of  pab-1  increased throughout postembryonic development and its protein expression was germline-enriched. PAB-1 localized to P granules and the cytoplasm in the germline. PAB-1 colocalized with CGH-1 and CAR-1 and affected their localization, suggesting that PAB-1 is a component of processing (P)-bodies that interacts with them. The mRNA and protein levels of representative germline genes,  rec-8 ,  GLP-1 ,  rme-2 , and  msp-152 , were decreased after  pab-1  RNAi. Although the mRNA level of  msp-152  was increased in  cgh-1  mutant, it was also significantly reduced by  pab-1  RNAi. Our results suggest that PAB-1 positively regulates the mRNA levels of germline genes, which is likely facilitated by the interaction of PAB-1 with other P-body components, CGH-1 and CAR-1.

PAB-1, a Caenorhabditis elegans Poly(A)-Binding Protein, Regulates mRNA Metabolism in germline by Interacting with CGH-1 and CAR-1