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Objective  To investigate the association of Mannose-binding lectin ( MBL ) and the  MBL2  gene with type 2 diabetes and diabetic nephropathy and the influence of  MBL2  polymorphisms on serum  MBL  levels.    Methods  The study population included 675 type 2 diabetic patients with or without nephropathy and 855 normoglycemic controls. The single nucleotide polymorphisms (SNPs) of rs1800450, rs1800451, and rs11003125 of the  MBL2  gene were determined by the Multiplex Snapshot method. Serum  MBL  levels were measured by enzyme-linked immune sorbent assay.    Results  Rs1800450 and rs11003125 SNPs demonstrated strong linkage disequilibrium in the study population (r 2  = 0.97). The haplotypes constructed from the G allele of rs1800450 and the C allele of rs11003125 increased the risk for type 2 diabetes ( OR  = 1.2, 95%  CI  = 1.1–1.4,  P =  0.01). For rs1800450, GG and GA genotypes were associated with type 2 diabetes ( P =  0.02, 0.01, respectively). For rs11003125, the GC genotype frequency was significantly different between patients and controls (18.1% vs. 24.9%,  P =  0.001). Analyses of genotypes and allele frequency distributions among patients with normal UAE, microalbuminuria, and macroalbuminuria showed that there was no obvious evidence of association between the  MBL2  gene and diabetic nephropathy. Subjects with the GG genotype of rs1800450 and the CC genotype of rs11003125 had much higher serum  MBL  levels.    Conclusions  The rs1800450 and rs11003125 SNPs of the  MBL2  gene have strong linkage disequilibrium and are associated with type 2 diabetes in the North Chinese Han population. No association was observed between the  MBL2  gene and diabetic nephropathy. Subjects with the GG genotype of rs1800450 and the CC genotype of rs11003125 had much higher serum MBL levels. An association between elevated serum  MBL  and diabetic nephropathy was also observed.

Association of Levels of Mannose-Binding Lectin and the MBL2 Gene with Type 2 Diabetes and Diabetic Nephropathy