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Despite the important diagnostic value of evaluating antibody responses to individual human pathogens, antibody profiles against multiple infectious agents have not been used to explore health and disease mainly for technical reasons.  We hypothesized that the interplay between infection and chronic disease might be revealed by profiling antibodies against multiple agents. Here, the levels of antibodies against a panel of 13 common infectious agents were evaluated with the quantitative Luciferase Immunoprecipitation Systems (LIPS) in patients from three disease cohorts including those with pathogenic anti-interferon-γ autoantibodies (IFN-γ AAB), HIV and Sjögren’s syndrome (SjS) to determine if their antibody profiles differed from control subjects.  The IFN-γ AAB patients compared to controls demonstrated statistically higher levels of antibodies against VZV ( p =0.0003), EBV ( p =0.002), CMV ( p =0.003), and C. albicans ( p =0.03), but lower antibody levels against poliovirus ( p =0.04). Comparison of HIV patients with blood donor controls revealed that the patients had higher levels of antibodies against CMV ( p =0.0008), HSV-2 ( p =0.0008), EBV ( p =0.001), and C. albicans ( p =0.01), but showed decreased levels of antibodies against coxsackievirus B4 ( p =0.0008), poliovirus ( p =0.0005),   and HHV-6B ( p =0.002). Lastly, SjS patients had higher levels of anti-EBV antibodies ( p =0.03), but lower antibody levels against several enteroviruses including a newly identified picornavirus, HCoSV-A ( p =0.004), coxsackievirus B4 ( p =0.04), and poliovirus ( p =0.02). For the IFN-γ AAB and HIV cohorts, principal component analysis revealed unique antibody clusters that showed the potential to discriminate patients from controls.  The results suggest that antibody profiles against these and likely other common infectious agents may yield insight into the interplay between exposure to infectious agents, dysbiosis, adaptive immunity and disease activity.

Altered Antibody Profiles against Common Infectious Agents in Chronic Disease