English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Esophageal cancer is the eighth most common cancer and sixth leading cause of cancer associated death worldwide. Besides environmental risk factors, genetic factors might play an important role in the esophageal cancer carcinogenesis. We conducted a hospital based case–control study to evaluate the genetic susceptibility of functional single nucleotide polymorphisms (SNPs) in the microRNAs on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were recruited for this study. The  hsa-miR-34b/c  rs4938723 T>C,  pri-miR-124-1  rs531564 C>G,  pre-miR-125a  rs12975333 G>T and  hsa-miR-423  rs6505162 C>A genotypes were determined using Ligation Detection Reaction (LDR) method. Our results demonstrated that  hsa-miR-34b/c  rs4938723 CC genotype had a decreased risk of ESCC. The association was evident among patients who never drinking.  Hsa-miR-423  rs6505162 C>A might associated with a significantly increased risk of ESCC in patients who smoking. These findings indicated that functional polymorphisms  hsa-miR-34b/c  rs4938723 T>C and  hsa-miR-423  rs6505162 C>A might alter individual susceptibility to ESCC. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations are required to confirm current findings.

plos one

Hsa-miR-34b/c rs4938723 T&gt;C and hsa-miR-423 rs6505162 C&gt;A Polymorphisms Are Associated with the Risk of Esophageal Cancer in a Chinese Population