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Background  Tumor necrosis factor-α (TNF-α) 308 G/A gene polymorphism has been reported to be associated with susceptibility to silicosis. However, the relevant study results are still inconsistent.    Objective and Methods  A meta-analysis was performed in order to drive a more precise estimation of the relationship between TNF-α-308 G/A gene polymorphism and susceptibility to silicosis. Electronic databases were searched and nine separate studies were included. The pooled odds ratios (ORs) and the corresponding 95% confidence internal (CI) were calculated by a fixed effect model.    Results  A total of 1267 cases and 1214 controls were included. In the overall analysis, significantly increased silicosis risk was found (for GA+AA vs. GG  OR =1.45, 95%CI: 1.20-1.760,  P =1.58E4; for GA vs. GG: OR=1.53, 95%CI=1.25-1.86,  P =3.11E5; for A allele vs. G allele: OR=1.27, 95%CI=1.08-1.50,  P = 0.004). In the subgroup analysis, significantly increased silicosis risk was also found among Asians (for GA+AA vs. GG: OR=1.63, 95%CI=1.27-2.08,  P =1.01E4), for GA vs. GG: OR=1.71, 95%CI=1.33-2.20,  P =3.44E5), for A allele vs. G allele: OR=1.45, 95%CI=1.17-1.80,  P =0.001). However, no significantly increased risk was found among non-Asians for all genetic models.    Conclusions  TNF-α-308 G/A polymorphism might lead to an increased risk of silicosis susceptibility, especially for Asians. However, further studies with large sample sizes should be conducted to confirm the association.

Association between Tumor Necrosis Factor-α 308G/A Gene Polymorphism and Silicosis Susceptibility: A Meta-Analysis