English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Purpose  To determine the optimal standardized uptake value (SUV) of  18 F-fluorodeoxyglucose ( 18 F-FDG) for positron emission tomography (PET) imaging, at which the PET-defined gross tumor volume (GTV PET ) best matches with the pathological volume (GTV PATH ) in the cervical cancer.    Materials and Methods  Ten patients with the cervical cancer who underwent surgery were enrolled in this study. The excised specimens were processed for whole-mount serial sections and H-E staining. The tumor borders were outlined in sections under a microscope, histopathological images were scanned and the GTV PATH  calculated. The GTV PET  was delineated automatically by using various percentages relative to the maximal SUV and absolute SUV. The optimal threshold SUV was further obtained as the value at which the GTV PET  best matched with the GTV PATH .    Results  An average of 85±10% shrinkage of tissue was observed after the formalin fixation. The GTV PATH  was 13.38±2.80 cm 3  on average. The optimal threshold on percentile SUV and absolute SUV were 40.50%±3.16% and 7.45±1.10, respectively. The correlation analysis showed that the optimal percentile SUV threshold was inversely correlated with GTV PATH  (p<0.05) and tumor diameter (p<0.05). The absolute SUV was also positively correlated with SUV max  (p<0.05).    Conclusion  The pathological volume could provide the more accurate tumor volume. The optimal SUV of FDG for PET imaging by use of GTV PATH  as standard for cervical cancer target volume delineation was thus determined in this study, and more cases are being evaluated to substantiate this conclusion.

plos one

Determination of an Optimal Standardized Uptake Value of Fluorodeoxyglucose for Positron Emission Tomography Imaging to Assess Pathological Volumes of Cervical Cancer: A Prospective Study