English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Oral leukoplakias are histopathologically-diagnosed as  Candida  leukoplakia or non- Candida  leukoplakia by the presence or absence of hyphae in the superficial epithelium.  Candida  leukoplakia lesions have significantly increased malignant potential.  Candida albicans  is the most prevalent fungal species associated with oral leukoplakia and may contribute to malignant transformation of  Candida  leukoplakia. To date, no detailed population analysis of  C. albicans  isolates from oral leukoplakia patients has been undertaken. This study investigated whether specific  C. albicans  genotypes were associated with  Candida  leukoplakia and non- Candida  leukoplakia in a cohort of Irish patients. Patients with histopathologically-defined  Candida  leukoplakia (n = 31) or non- Candida  leukoplakia (n = 47) were screened for  Candida  species by culture of oral rinse and lesional swab samples. Selected  C. albicans  isolates from  Candida  leukoplakia patients (n = 25), non- Candida  leukoplakia patients (n = 19) and oral carriage isolates from age and sex matched healthy subjects without leukoplakia (n = 34) were subjected to multilocus sequence typing (MLST) and ABC genotyping. MLST revealed that the clade distribution of  C. albicans  from both  Candida  leukoplakia and non- Candida  leukoplakia lesions overlapped with the corresponding clade distributions of oral carriage isolates and global reference isolates from the MLST database indicating no enrichment of leukoplakia-associated clones. Oral leukoplakia isolates were significantly enriched with ABC genotype C (12/44, 27.3%), particularly  Candida  leukoplakia isolates (9/25, 36%), relative to oral carriage isolates (3/34, 8.8%). Genotype C oral leukoplakia isolates were distributed in MLST clades 1,3,4,5,8,9 and 15, whereas genotype C oral carriage isolates were distributed in MLST clades 4 and 11.

plos one

Genotyping Candida albicans from Candida Leukoplakia and Non-Candida Leukoplakia Shows No Enrichment of Multilocus Sequence Typing Clades but Enrichment of ABC Genotype C in Candida Leukoplakia