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Background  The I405V polymorphism of the cholesteryl ester transfer protein gene ( CETP ) has been suggested to be a protective factor conferring longevity in Ashkenazi Jews, although findings in other races are not supportive. This paper describes a case-control study and a meta-analysis conducted to derive a more precise estimation of the association between  CETP  405V and longevity.    Methods  We enrolled 1,021 ethnic Han Chinese participants (506 in the longevity group and 515 controls), then performed a meta-analysis that integrated the current study and previously published ones. Pooled odds ratios (OR) were calculated for allele contrasts, dominant and recessive inheritance models to assess the association between  CETP  405V and longevity according to the ethnic stratification.    Results  Our case-control data indicated that  CETP  405V is a longevity risk allele in all genetic models ( P    additive  =0.008;  P    dominant  =0.008, OR dominant =0.673;  P    recessive  =0.017, OR recessive =0.654) after adjustment for the apolipoprotein E ( APOE ) ε4 allele, body mass index and high-density lipoprotein cholesterol. A synergy was detected between 405V and  APOE  ε4 ( P =0.001, OR=0.530). Eight studies were eligible for meta-analysis, which confirmed 405V is the risky allele against longevity in all genetic models: allele contrasts (OR=0.81, 95%CI=0.74-0.88), dominant model (OR=0.72, 95%CI=0.64-0.82) and recessive model (OR=0.80, 95%CI=0.67-0.96). After ethnic stratification, 405V remained a risk allele in East Asians but no significant association was found in Europeans or white Americans.    Conclusion  Our case-control study suggests  CETP  405V as a risk allele against longevity in Chinese. The meta-analysis suggests the involvement of  CETP  405V is protective in Ashkenazi Jews but is a risk allele against longevity in the East Asian (Chinese) population.

Trans-Ethnical Shift of the Risk Genotype in the CETP I405V with Longevity: A Chinese Case-Control Study and Meta-Analysis