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Aims  The goal of our study is to investigate the combined contribution of 10 genetic variants to diabetes susceptibility.    Methods  Bibliographic databases were searched from 1970 to Dec 2012 for studies that reported on genetic association study of diabetes. After a comprehensive filtering procedure, 10 candidate gene variants with informative genotype information were collected for the current meta-anlayses. Using the REVMAN software, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the combined contribution of the selected genetic variants to diabetes.    Results  A total of 37 articles among 37,033 cases and 54,716 controls were involved in the present meta-analyses of 10 genetic variants. Three variants were found to be significantly associated with type 1 diabetes (T1D):  NLRP1  rs12150220 (OR = 0.71, 95% CI = 0.55–0.92, P = 0.01),  IL2RA  rs11594656 (OR = 0.86, 95% CI = 0.82–0.91, P<0.00001), and  CLEC16A  rs725613 (OR = 0.71, 95% CI = 0.55–0.92, P = 0.01).  APOA5  −1131T/C polymorphism was shown to be significantly associated with of type 2 diabetes (T2D, OR = 1.27, 95% CI = 1.03–1.57, P = 0.03). No association with diabetes was showed in the meta-analyses of other six genetic variants, including  SLC2A10  rs2335491,  ATF6  rs2070150,  KLF11  rs35927125,  CASQ1  rs2275703,  GNB3  C825T, and  IL12B  1188A/C.    Conclusion  Our results demonstrated that  IL2RA  rs11594656 and  CLEC16A  rs725613 are protective factors of T1D, while  NLRP1  rs12150220 and  APOA5  −1131T/C are risky factors of T1D and T2D, respectively.

Genetic Associations with Diabetes: Meta-Analyses of 10 Candidate Polymorphisms