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Toxoplasma gondii  is an opportunistic intracellular parasite that is highly prevalent in human and warm-blooded animals throughout the world, leading to potentially severe congenital infections. Although the abortion caused by  T. gondii  is believed to be dependent on the timing of maternal infection during pregnancy, the mechanism remains unclear. This study was focused on the effects of  T. gondii  excreted-secreted antigens on pregnant outcomes and CD4 + CD25 +  Foxp3 +  regulatory T cells at different stages of pregnancy. The results showed that in mice the frequency and suppressive function of CD4 + CD25 +  regulatory cells were diminished after injection of  T. gondii  excreted-secreted antigens at early and intermediate stages of pregnancy. The abortion caused by  T. gondii  excreted-secreted antigens at early pregnancy could be partly prevented by adoptively transferring of CD4 + CD25 +  cells from the mice injected with  T. gondii  excreted-secreted antigens at late pregnancy, but not from the mice with the same treatment at early pregnancy. Furthermore,  T. gondii  excreted-secreted antigens induced apoptosis of CD4 + CD25 +  regulatory cells of mice in early and intermediate stages of pregnancy by down-regulating their Bcl-2 expressions and Bcl-2/Bax ratio. This study provides new insights into the mechanism that  T. gondii  infection is the high risk factor for abortion in early pregnancy.

plos one

The Dysfunction of CD4+CD25+ Regulatory T Cells Contributes to the Abortion of Mice Caused by Toxoplasma gondii Excreted-Secreted Antigens in Early Pregnancy