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Mannitol (Mtl) fermentation, with the subsequent production of acid, is a species signature of  Staphylococcus aureus , and discriminates it from most other members of the genus. Inactivation of the gene  mtlD,  encoding Mtl-1-P dehydrogenase was found to markedly reduce survival in the presence of the antimicrobial fatty acid, linoleic acid. We demonstrate that the sugar alcohol has a potentiating action for this membrane-acting antimicrobial. Analysis of cellular metabolites revealed that, during exponential growth, the  mtlD  mutant accumulated high levels of Mtl and Mtl-P. The latter metabolite was not detected in its isogenic parent strain or a deletion mutant of the entire  mtlABFD  operon. In addition, the  mtlD  mutant strain exhibited a decreased MIC for H 2 O 2 , however virulence was unaffected in a model of septic arthritis.

Mannitol Utilisation is Required for Protection of Staphylococcus aureus from Human Skin Antimicrobial Fatty Acids