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Epiblast stem cells (EpiSCs) and embryonic stem cells (ESCs) differ in their  in vivo  differentiation potential. While ESCs form teratomas and efficiently contribute to the development of chimeras, EpiSCs form teratomas but very rarely chimeras. In contrast to their differentiation potential, the reprogramming potential of EpiSCs has not yet been investigated. Here we demonstrate that the epiblast-derived pluripotent stem cells EpiSCs and P19 embryonal carcinoma cells (ECCs) exhibit a lower reprogramming potential than ESCs and F9 ECCs. In addition, we show that the low reprogramming ability is due to the lower levels of  Sox2  in epiblast-derived stem cells. Consistent with this observation, overexpression of  Sox2  enhances reprogramming efficiency. In summary, these findings suggest that a low reprogramming potential is a general feature of epiblast-derived stem cells and that the  Sox2  level is a determinant of the cellular reprogramming potential.

Sox2 Level Is a Determinant of Cellular Reprogramming Potential