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DNA repair is a key determinant in the cellular response to therapy and tumor repair status could play an important role in tailoring patient therapy. Our goal was to evaluate the mRNA of 13 genes involved in different DNA repair pathways (base excision, nucleotide excision, homologous recombination, and Fanconi anemia) in paraffin embedded samples of triple negative breast cancer (TNBC) compared to luminal A breast cancer (LABC). Most of the genes involved in nucleotide excision repair and Fanconi Anemia pathways, and  CHK1  gene were significantly less expressed in TNBC than in LABC.  PARP1  levels were higher in TNBC than in LABC. In univariate analysis high level of  FANCA  correlated with an increased overall survival and event free survival in TNBC; however multivariate analyses using Cox regression did not confirm  FANCA  as independent prognostic factor. These data support the evidence that TNBCs compared to LABCs harbour DNA repair defects.

Triple Negative Breast Cancers Have a Reduced Expression of DNA Repair Genes