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Objective  The antiseptic effect of gastric irrigation before endoscopic submucosal dissection (ESD) has not yet been reported. The aim of the randomized prospective study is to evaluate the antiseptic effects of gastric irrigation of saline solution before ESD by evaluating bacterial count.    Methods  This prospective randomized controlled trial included 50 patients diagnosed with early gastric cancer who were randomly divided into 2 groups (25 patients in each group) by using the opaque envelope method: the clean group (irrigation with 2 L saline solution before ESD) and the regular group (no irrigation). The gastric juice was collected and cultured before ESD. The entire stomach was irrigated using a water jet attached to an endoscope. After ESD with resection and removal of the tumor specimen, a postoperative culture of the gastric juice was obtained using the same method as the preoperative culture.    Results  The mean log bacterial count of the post-gastric irrigation gastric juice was 5.08±0.75 in the regular group and 1.86±0.86 in the clean group. The difference in the bacterial counts was significant between the groups ( P  = 0.0004). The difference in the white blood cells (WBC) count on POD 1 was significant ( P  = 0.044). WBC count on POD 2 did not significantly differ between the groups ( P  = 0.3). The difference in the body temperature (BT) on POD 1 was significant ( P  = 0.017), On POD 2 the BT was not significant between the groups ( P  = 0.5). On POD 1, 88% of the patients in the regular group and 16% of the patients in the clean group had mild to moderate spontaneous pain ( P  = 0.0026). On POD 2 the proportion with mild to moderate spontaneous pain was 36% and 24% in the regular group and the clean group, respectively ( P  = 0.1).    Conclusion  Pre-ESD gastric irrigation with saline solution is effective and feasible for suppressing infection during the ESD procedure with favorable clinical outcomes.    Trial registration information  The university hospital medical information network (UMIN) #8691.

Effects of Gastric Irrigation on Bacterial Counts before Endoscopic Submucosal Dissection: A Randomized Case Control Prospective Study