English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background & Aims  We previously demonstrated the pro-metastasis effect of sorafenib in hepatocellular carcinoma (HCC), which is mediated by down-regulation of tumor suppressor  HTATIP2 . The aim of the present study was to determine whether aspirin minimizes this effect and improves survival.    Methods  The effects of sorafenib, aspirin, and combined sorafenib and aspirin were observed in HCCLM3 and HepG2 xenograft nude mice. Tumor growth, intrahepatic metastasis (IHM), lung metastasis, and survival were assessed. Polymerase chain reaction (PCR) array, real-time (RT)-PCR, and Western blotting were used to examine gene expression. The anti-invasion and anti-metastasis effects of aspirin were studied in  HTATIP2 -knockdown and  HTATIP2 -overexpressing HCC cell lines. The molecular mechanism of  HTATIP2  regulation by aspirin was explored.    Results  Aspirin suppressed the pro-invasion and pro-metastasis effects of sorafenib in HCC and up-regulated  HTATIP2  expression. Aspirin did not inhibit the proliferation of HCC cells, but it decreased the invasiveness of HCC with lower expression of  HTATIP2  and increased expression of a set of markers, indicating a mesenchymal-to-epithelial transition in tumor cells. The up-regulation of  HTATPI2  expression by aspirin is most likely mediated through inhibition of cyclooxygenase (COX) 2 expression.    Conclusions  Aspirin minimized the pro-metastasis effect of sorafenib by up-regulating the tumor suppressor  HTATIP2 ; this mechanism is mediated through inhibition of COX2.

Aspirin Minimized the Pro-Metastasis Effect of Sorafenib and Improved Survival by Up-Regulating HTATIP2 in Hepatocellular Carcinoma