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Background  The ANP32 family of proteins have been implicated in neuronal function through biochemical and cellular biology studies in neurons, as well as by recent behavioural studies of a gene-trapped loss-of-function mutation of  Anp32e  in mice, particularly with respect to fine motor function. A second targeted allele of the  Anp32e , however, did not appear to demonstrate neurological phenotypes.    Methodology/Principal Findings  Using a stringently controlled cohort of ten-generation backcrossed, co-caged, sex-matched, littermate pairs, we assayed for potential motor defects in the targeted ANP32E-deficient mice. We found no phenotypic difference in any assays.    Conclusion  Since it is unlikely that the gene-trap is a more complete loss-of-function, our results suggest that ANP32E has no appreciable effect on motor functions and that genetic background differences most likely account for the gene-trap phenomena.

Targeted ANP32E Mutant Mice Do Not Demonstrate Obvious Movement Defects