English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  MicroRNAs (miRNAs) have been implicated in various human diseases. Single nucleotide polymorphisms (SNPs) in inflammation-related miRNA may play an important role in  Helicobacter pylori  ( H. pylori )-induced gastric lesions. To evaluate the associations between miRNA SNPs,  H. pylori  and gastric lesions, a population-based study was conducted in Linqu County, China.    Methodology/Principal Findings  Based on serum miRNA array conducted in this population, two SNP loci ( miR-146a  rs2910164: G>C and  miR-27a  rs895819: T>C) were determined by polymerase chain reaction-restriction fragment length polymorphism in 2,380 participants with diverse gastric lesions. Using participants with superficial gastritis and mild chronic atrophic gastritis as the reference group, we found that rs2910164 CC carriers had a significantly increased risk of intestinal metaplasia [adjusted odds ratio (OR), 1.42; 95% confidence interval (CI), 1.03–1.97] and dysplasia (OR, 1.54; 95% CI, 1.05–2.25) compared to GG carriers, whereas no significant association was observed for rs895819. Stratified analysis by  H. pylori  infection indicated that rs2910164 C allele was associated with an increased risk of intestinal metaplasia and dysplasia only among individuals infected with  H. pylori  (CC vs. GG: OR, 1.53; 95% CI, 1.12–2.08,  P  for trend = 0.004). Participants who simultaneously carried variant alleles and  H. pylori  infection were more likely to develop intestinal metaplasia and dysplasia, although the interaction between genetic variants and  H. pylori  infection was not significant ( P  for interaction = 0.35 for rs2910164 and 0.92 for rs895819).    Conclusions/Significance  These findings suggest that  miR-146a  rs2910164 polymorphism may contribute to the evolution of  H. pylori -associated gastric lesions in this high-risk population.

Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population