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Background  Although  adiponectin  −11377CG gene polymorphism is implied to be associated with increased type 2 diabetes mellitus (T2DM) risk, results of individual studies are inconsistent.    Objective and Methods  A meta-analysis consisting of 12 individual studies, including a total of 6425 participants, was carried out in order to investigate the association of  adiponectin  −11377CG gene polymorphism with T2DM. The pooled odds ratio (OR) and its corresponding confidence interval (CI) at 95% were assessed through the random- or fixed- effect model.    Results  A significant relationship was observed between  adiponectin  −11377CG gene polymorphism and T2DM under allelic (OR: 1.150, 95% CI: 1.060 to 1.250,  P  = 0.001), recessive (OR: 1.450, 95% CI: 1.180–1.770,  P  = 0.0004), dominant (OR: 1.071, 95% CI: 1.013–1.131,  P  = 0.015), additive (OR: 1.280, 95% CI: 1.090–1.510,  P  = 0.002), and homozygous genetic models (OR: 1.620, 95% CI: 1.310–1.990,  P <0.00001). No significant association was found between them under the heterozygous genetic model (OR: 1.640, 95% CI: 0.850–3.170,  P  = 0.140).    Conclusions    Adiponectin  −11377CG gene polymorphism was significantly associated with T2DM risk susceptibility. G allele carriers are predisposed to T2DM risk.

Adiponectin-11377CG Gene Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis of 6425 Subjects