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B-1 cells are innate-like cells that play important roles in host defense against infection. However, the function of B-1 cells in fungi infection remains unclear. Previously we produced IgH transgenic mice TgV H 3B4 with V H  derived from a natural antibody 3B4 that can identify  C. albicans , and found that TgV H 3B4 mice were resistant to intraperitoneal (i. p.) and intravenous  C. albicans  infection. Most of the peritoneal cavity (PEC) B-1 cells in TgV H 3B4 mice express transgenic BCR that binds  C. albicans . In the present study, we explored the response of B-1 cells to  C. albicans  infection by applying i. p. inoculation of fungi in TgV H 3B4 mice. We found that  C. albicans  was cleared more efficiently in TgV H 3B4 mice after i. p. inoculation than that of littermate control. The level of  C. albicans -reactive IgM in PEC of TgV H 3B4 mice was much higher than that of control, and the number of B-1a B cells was also elevated in TgV H 3B4 mice, which was mainly due to enhanced proliferation of B-1 cells. Additionally, numbers of  C. albicans -specific B cells increased greatly in TgV H 3B4 mice after  C. albicans  inoculation. Our data suggested that in situ IgM production and clonal expansion of B-1 cells in PEC participate in host defense against  C. albicans  infection.

plos one

In Situ IgM Production and Clonal Expansion of B-1 Cells in Peritoneal Cavity Promote Elimination of C. albicans Infection in IgH Transgenic Mice with VH Derived from a Natural Antibody