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Linezolid is an effective antimicrobial agent to treat methicillin-resistant  Staphylococcus aureus  (MRSA). Resistance to linezolid due to the  cfr  gene is described worldwide. The present study aimed to analyze the prevalence of the  cfr –mediated linezolid resistance among MRSA clinical isolates in our area. A very low prevalence of  cfr  mediated linezolid resistance was found: only one bacteremic isolate out of 2 215 screened isolates. The only linezolid resistant isolate arose in a patient, previously colonized by MRSA, following linezolid therapy. Despite the low rate of resistance in our area, ongoing surveillance is advisable to avoid the spread of linezolid resistance.

plos one

Low Prevalence of Cfr-Mediated Linezolid Resistance among Methicillin-Resistant Staphylococcus aureus in a Spanish Hospital: Case Report on Linezolid Resistance Acquired during Linezolid Therapy