English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Purpose  To describe the frequency of  MLH1  promoter methylation in colorectal cancer (CRC); to explore the associations between  MLH1  promoter methylation and clinicopathological and molecular factors using a systematic review and meta-analysis.    Methods  A literature search of the PubMed and Embase databases was conducted to identify relevant articles published up to September 7, 2012 that described the frequency of  MLH1  promoter methylation or its associations with clinicopathological and molecular factors in CRC. The pooled frequency, odds ratio (OR) and 95% confidence intervals (95% CI) were calculated.    Results  The pooled frequency of  MLH1  promoter methylation in unselected CRC was 20.3% (95% CI: 16.8–24.1%). They were 18.7% (95% CI: 14.7–23.6%) and 16.4% (95% CI: 11.9–22.0%) in sporadic and Lynch syndrome (LS) CRC, respectively. Significant associations were observed between  MLH1  promoter methylation and gender (pooled OR = 1.641, 95% CI: 1.215–2.215;  P  = 0.001), tumor location (pooled OR = 3.804, 95% CI: 2.715–5.329;  P <0.001), tumor differentiation (pooled OR = 2.131, 95% CI: 1.464–3.102;  P <0.001), MSI (OR: 27.096, 95% CI: 13.717–53.526;  P <0.001). Significant associations were also observed between  MLH1  promoter methylation and  MLH1  protein expression,  BRAF  mutation (OR = 14.919 (95% CI: 6.427–34.631;  P <0.001) and 9.419 (95% CI: 2.613–33.953;  P  = 0.001), respectively).    Conclusion  The frequency of  MLH1  promoter methylation in unselected CRC was 20.3%. They were 18.7% in sporadic CRC and 16.4% in LS CRC, respectively.  MLH1  promoter methylation may be significantly associated with gender, tumor location, tumor differentiation, MSI,  MLH1  protein expression, and  BRAF  mutation.

MLH1 Promoter Methylation Frequency in Colorectal Cancer Patients and Related Clinicopathological and Molecular Features