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Aims  We aimed to replicate the association of the rs290487 (IVS3C/T) and rs7903146 (IVS3C/T) polymorphisms of transcription factor 7-like 2 ( TCF7L2 ) and type 2 diabetes mellitus (T2DM) in Han Chinese people in Henan province, China.    Methods  In all, 1,842 patients with T2DM and 7,777 normal glucose-tolerant controls underwent genotyping for the T2DM-associated variants rs7903146 (IVS3C/T) and rs290487 (IVS3C/T). W performed a meta-analysis of the association of the risk alleles of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in  TCF7L2  and T2DM in Han Chinese by combining previous studies with the present study.    Results  We found that T2DM was associated with the CC genotype (1.364, 1.137–1.636,  p   = 0.001), the recessive model (1.457, 1.156–1.838,  p   = 0.001) of rs290487 (IVS3C/T) and haplotype CC (1.116, 1.034–1.204,  p   = 0.004) in Han Chinese. Moreover, our meta-analyses supported the association of the T allele (IVS3C/T) of rs7903146 (1.36, 1.24–1.48;  p   = 6.404×10 −12 ) and T2DM but not the C allele of rs290487 (IVS3C/T) (0.99, 0.85–1.15,  p   = 0.890) in Han Chinese. We found no interactions between behavioral risk factors (smoking, alcohol drinking, and physical activity) and rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) polymorphisms.    Conclusions  The CC genotype and the recessive model of the variant rs290487 (IVS3C/T) and CC haplotype of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) in  TCF7L2  may be associated with T2DM in Han Chinese people in Henan province, China.

Association of rs7903146 (IVS3C/T) and rs290487 (IVS3C/T) Polymorphisms in TCF7L2 with Type 2 Diabetes in 9,619 Han Chinese Population