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Objectives  To investigate the relationship between endogenous androgens and body fat distribution in early and late postmenopausal women.    Materials and Methods  We enrolled postmenopausal women consisting of an early group (≤5 years since menopause, n = 105) and a late group (≥10 years since menopause, n = 107). Each group was subdivided into normal weight (BMI <24 kg/m 2 ) group, overweight and obese (BMI ≥24 kg/m 2 ) group. Fasting total testosterone (T), dehydroepiandrosterone-sulfate (DHEA-S) and sex hormone-binding globulin (SHBG) levels were measured. Body fat distribution was evaluated by dual-energy X-ray absorptiometry (DEXA).    Results  Late postmenopausal women had a higher proportion of body fat than early postmenopausal women. The body fat of the overweight and obese women had a greater tendency to accumulate in the abdomen compared with the normal weight women both in early and late postmenopausal groups. The overweight and obese women had a higher free testosterone (FT) than the normal weight women in early postmenopausal women ( P <0.05). In late postmenopausal women, the overweight and obese women had higher DHEA-S levels than normal weight women ( P <0.05). No direct relationship was observed between the T levels and body fat distribution both in early and late postmenopausal groups ( P >0.05).The FT in early postmenopausal women and the DHEA-S levels in late postmenopausal women correlated positively with the trunk/leg fat ratio (T/L) and the proportion of android fat whereas correlated negatively with the proportion of gynoid fat in the partial correlation and multiple linear regression analyses (all  P <0.05).    Conclusions  Serum T levels do not correlate directly with body fat distribution, the FT in early postmenopausal women and DHEA-S levels in late postmenopausal women correlate positively with abdominal fat accumulation.

The Relationship between Endogenous Androgens and Body Fat Distribution in Early and Late Postmenopausal Women