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The aim of this study was to determine a genetic basis for IgA concentration in milk of  Bos taurus . We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide significant QTL on chromosome 16, maximising at 4.8 Mbp. The polymeric immunoglobulin receptor gene (PIGR) was within the confidence interval of the QTL. In addition, mRNA expression analysis revealed a liver  PIGR  expression QTL mapping to the same locus as the IgA quantitative trait locus. Sequencing and subsequent genotyping of the  PIGR  gene revealed three divergent haplotypes that explained the variance of both the IgA QTL and the  PIGR  expression QTL. Genetic selection based on these markers will facilitate the production of bovine herds producing milk with higher concentrations of IgA.

A Triad of Highly Divergent Polymeric Immunoglobulin Receptor (PIGR) Haplotypes with Major Effect on IgA Concentration in Bovine Milk