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Genes involved in sex determination and differentiation have been identified in mice, humans, chickens, reptiles, amphibians and teleost fishes. However, little is known of their functional conservation, and it is unclear whether there is a common set of genes shared by all vertebrates. Coelacanths, basal Sarcopterygians and unique “living fossils”, could help establish an inventory of the ancestral genes involved in these important developmental processes and provide insights into their components. In this study 33 genes from the genome of  Latimeria chalumnae  and from the liver and testis transcriptomes of  Latimeria menadoensis , implicated in sex determination and differentiation, were identified and characterized and their expression levels measured.  Interesting findings were obtained for  GSDF , previously identified only in teleosts and now characterized for the first time in the sarcopterygian lineage;  FGF9 , which is not found in teleosts; and  DMRT1 , whose expression in adult gonads has recently been related to maintenance of sexual identity. The gene repertoire and testis-specific gene expression documented in coelacanths demonstrate a greater similarity to modern fishes and point to unexpected changes in the gene regulatory network governing sexual development.

Characterization of Sex Determination and Sex Differentiation Genes in Latimeria