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Cellular retinoic acid binding protein 2 ( CRABP 2), a member of a family of specific carrier proteins for Vitamin A, belongs to a family of small cytosolic lipid binding proteins. Our previous study suggested that  CRABP2  was involved in skeletal muscle development; however, the molecular function and regulatory mechanism of  CRABP 2 in myogenesis remained unclear. In this study, we found that the expression of the  CRABP2  gene was upregulated during C2C12 differentiation. An over-expression assay revealed that  CRABP2  promotes myogenic transformation by regulating the cell cycle during C2C12 differentiation. The region from −459 to −4 bp was identified as the core promoter and contains a TATA box, a GC box and binding sites for the transcription factors MyoD and Sp1. Over-expression, site-directed mutagenesis and EMSA assays indicated that the transcription factors MyoD and Sp1 regulate  CRABP 2 expression and promote myoblast differentiation in C2C12 cells.

CRABP2 Promotes Myoblast Differentiation and Is Modulated by the Transcription Factors MyoD and Sp1 in C2C12 Cells