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Janthinobacteria commonly form biofilms on eukaryotic hosts and are known to synthesize antibacterial and antifungal compounds.  Janthinobacterium  sp. HH01 was recently isolated from an aquatic environment and its genome sequence was established. The genome consists of a single chromosome and reveals a size of 7.10 Mb, being the largest janthinobacterial genome so far known. Approximately 80% of the 5,980 coding sequences (CDSs) present in the HH01 genome could be assigned putative functions. The genome encodes a wealth of secretory functions and several large clusters for polyketide biosynthesis. HH01 also encodes a remarkable number of proteins involved in resistance to drugs or heavy metals. Interestingly, the genome of HH01 apparently lacks the N-acylhomoserine lactone (AHL)-dependent signaling system and the AI-2-dependent quorum sensing regulatory circuit. Instead it encodes a homologue of the  Legionella - and  Vibrio -like autoinducer ( lqsA/cqsA ) synthase gene which we designated  jqsA . The  jqsA  gene is linked to a cognate sensor kinase ( jqsS ) which is flanked by the response regulator  jqsR . Here we show that a  jqsA  deletion has strong impact on the violacein biosynthesis in  Janthinobacterium  sp. HH01 and that a  jqsA  deletion mutant can be functionally complemented with the  V. cholera e  cqsA  and the  L. pneumophila lqsA  genes.

The Janthinobacterium sp. HH01 Genome Encodes a Homologue of the V. cholerae CqsA and L. pneumophila LqsA Autoinducer Synthases