English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Previous studies investigating the association between cytochrome P4502E1 ( CYP2E1 ) polymorphisms and the risk of alcoholic liver diseases (ALD) have yielded conflicting results. Thus, a meta-analysis was performed to clarify the association between  CYP2E1  polymorphisms and the risks of ALD.    Methods  A comprehensive literature search was conducted to identify the relevant studies. The fixed or random effect model was selected based on the heterogeneity test among studies. Publication bias was estimated using Begg’s funnel plots and Egger’s regression test.    Results  A total of 27 and 9 studies were finally included for the association between the  CYP2E1 Pst I/Rsa I  or  Dra I  polymorphisms and the risks of ALD, respectively. Overall, the combined results showed that homozygous genotype c2c2 was significantly associated with increase risk of ALD in worldwide populations (c2c2  vs.  c1c1: OR = 3.12, 95%CI 1.91–5.11) when ALD patients were compared with alcoholics without ALD. Significant associations between  CYP2E1 Pst I/Rsa I  polymorphism and ALD risk were also observed in Asians (c2c2  vs.  c1c1: OR = 4.11, 95%CI 2.32–7.29) and in Caucasians (c2c2/c1c2  vs.  c1c1: OR = 1.58, 95%CI 1.04–2.42) when ALD patients were compared with alcoholics without ALD. However, subgroup analysis stratified by ALD types showed that  CYP2E1 Pst I/Rsa I  polymorphism was not significantly associated with the risks of alcoholic cirrhosis (ALC). No significant association was observed between  CYP2E1 Dra I  polymorphism and ALD risks.    Conclusion  This meta-analysis suggested that  CYP2E1 Pst I/Rsa I  polymorphism might be not significantly associated with advanced form of ALD (ALC), but might be significantly associated with other form of ALD such as steatosis, hepatisis, fibrosis. Furthermore,  CYP2E1 Dra I  polymorphism might be not significantly associated with the ALD risks. Since potential confounders could not be ruled out completely, further studies were needed to confirm these results.

Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis