English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Corynebacterium pseudotuberculosis  is a facultative intracellular pathogen and the causative agent of several infectious and contagious chronic diseases, including caseous lymphadenitis, ulcerative lymphangitis, mastitis, and edematous skin disease, in a broad spectrum of hosts. In addition,  Corynebacterium pseudotuberculosis  infections pose a rising worldwide economic problem in ruminants. The complete genome sequences of 15  C. pseudotuberculosis  strains isolated from different hosts and countries were comparatively analyzed using a pan-genomic strategy. Phylogenomic, pan-genomic, core genomic, and singleton analyses revealed close relationships among pathogenic corynebacteria, the clonal-like behavior of  C. pseudotuberculosis  and slow increases in the sizes of pan-genomes. According to extrapolations based on the pan-genomes, core genomes and singletons, the  C. pseudotuberculosis  biovar  ovis  shows a more clonal-like behavior than the  C. pseudotuberculosis  biovar  equi . Most of the variable genes of the biovar  ovis  strains were acquired in a block through horizontal gene transfer and are highly conserved, whereas the biovar  equi  strains contain great variability, both intra- and inter-biovar, in the 16 detected pathogenicity islands (PAIs). With respect to the gene content of the PAIs, the most interesting finding is the high similarity of the pilus genes in the biovar  ovis  strains compared with the great variability of these genes in the biovar  equi  strains. Concluding, the polymerization of complete pilus structures in biovar  ovis  could be responsible for a remarkable ability of these strains to spread throughout host tissues and penetrate cells to live intracellularly, in contrast with the biovar  equi , which rarely attacks visceral organs. Intracellularly, the biovar  ovis  strains are expected to have less contact with other organisms than the biovar  equi  strains, thereby explaining the significant clonal-like behavior of the biovar  ovis  strains.

plos one

The Pan-Genome of the Animal Pathogen Corynebacterium pseudotuberculosis Reveals Differences in Genome Plasticity between the Biovar ovis and equi Strains