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It has previously been shown that nano-meter sized vesicles (30–100 nm), exosomes, secreted by antigen presenting cells can induce T cell responses thus showing the potential of exosomes to be used as immunological tools. Additionally, activated CD3 +  T cells can secrete exosomes that have the ability to modulate different immunological responses. Here, we investigated what effects exosomes originating from activated CD3 +  T cells have on resting CD3 +  T cells by studying T cell proliferation, cytokine production and by performing T cell and exosome phenotype characterization. Human exosomes were generated  in vitro  following CD3 +  T cell stimulation with anti-CD28, anti-CD3 and IL-2. Our results show that exosomes purified from stimulated CD3 +  T cells together with IL-2 were able to generate proliferation in autologous resting CD3 +  T cells. The CD3 +  T cells stimulated with exosomes together with IL-2 had a higher proportion of CD8 +  T cells and had a different cytokine profile compared to controls. These results indicate that activated CD3 +  T cells communicate with resting autologous T cells via exosomes.

Activated Human T Cells Secrete Exosomes That Participate in IL-2 Mediated Immune Response Signaling