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After the publication of this article, a number of concerns were raised in relation to different aspects of the research reported. The PLOS ONE editors carried out an evaluation of the history of the manuscript, which revealed that due to a failure in the peer review process, several aspects of the research were not adequately evaluated before publication. As a result, the PLOS ONE editors have undertaken a thorough re-examination of this study, involving both external and internal advisers. This assessment has revealed the following concerns regarding the study:

Expression of Concern: Novel Allelic Variants in the Canine Cyclooxgenase-2 (Cox-2) Promoter Are Associated with Renal Dysplasia in Dogs