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The dopamine D 1 , D 2 , D 3  receptors, vesicular monoamine transporter type-2 (VMAT2), and dopamine transporter (DAT) densities were measured in 11 aged human brains (aged 77–107.8, mean: 91 years) by quantitative autoradiography. The density of D 1  receptors, VMAT2, and DAT was measured using [ 3 H]SCH23390, [ 3 H]dihydrotetrabenazine, and [ 3 H]WIN35428, respectively. The density of D 2  and D 3  receptors was calculated using the D 3 -preferring radioligand, [ 3 H] WC-10  and the D 2 -preferring radioligand [ 3 H]raclopride using a mathematical model developed previously by our group. Dopamine D 1 , D 2 , and D 3  receptors are extensively distributed throughout striatum; the highest density of D 3  receptors occurred in the nucleus accumbens (NAc). The density of the DAT is 10–20-fold lower than that of VMAT2 in striatal regions. Dopamine D 3  receptor density exceeded D 2  receptor densities in extrastriatal regions, and thalamus contained a high level of D 3  receptors with negligible D 2  receptors. The density of dopamine D 1  linearly correlated with D 3  receptor density in the thalamus. The density of the DAT was negligible in the extrastriatal regions whereas the VMAT2 was expressed in moderate density. D 3  receptor and VMAT2 densities were in similar level between the aged human and aged rhesus brain samples, whereas aged human brain samples had lower range of densities of D 1  and D 2  receptors and DAT compared with the aged rhesus monkey brain. The differential density of D 3  and D 2  receptors in human brain will be useful in the interpretation of PET imaging studies in human subjects with existing radiotracers, and assist in the validation of newer PET radiotracers having a higher selectivity for dopamine D 2  or D 3  receptors.

Dopamine D1, D2, D3 Receptors, Vesicular Monoamine Transporter Type-2 (VMAT2) and Dopamine Transporter (DAT) Densities in Aged Human Brain