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S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1), also known as IP 3  receptor-binding protein released with IP 3  (IRBIT), regulates IP 3 -induced Ca 2+  release into the cytoplasm of cells. AHCYL1 is a critical regulator of early developmental stages in zebrafish, but little is known about the function of AHCYL1 or hormonal regulation of expression of the  AHCYL1  gene in avian species. Therefore, we investigated differential expression profiles of the  AHCYL1  gene in various adult organs and in oviducts from estrogen-treated chickens. Chicken  AHCYL1  encodes for a protein of 540 amino acids that is highly conserved and has considerable homology to mammalian AHCYL1 proteins (>94% identity).  AHCYL1  mRNA was expressed abundantly in various organs of chickens. Further, the synthetic estrogen agonist induced  AHCYL1  mRNA and protein predominantly in luminal and glandular epithelial cells of the chick oviduct. In addition, estrogen activated AHCYL1 through the ERK1/2 signal transduction cascade and that activated expression of AHCYL1 regulated genes affecting oviduct development in chicks as well as calcium release in epithelial cells of the oviduct. Also, microRNAs,  miR-124a, miR-1669, miR-1710  and  miR-1782  influenced  AHCYL1  expression  in vitro  via its 3′-UTR which suggests that post-transcriptional events are involved in the regulation of  AHCYL1  expression in the chick oviduct. In conclusion, these results indicate that  AHCYL1  is a novel estrogen-stimulated gene expressed in epithelial cells of the chicken oviduct that likely affects growth, development and calcium metabolism of the mature oviduct of hens via an estrogen-mediated ERK1/2 MAPK cell signaling pathway.

AHCYL1 Is Mediated by Estrogen-Induced ERK1/2 MAPK Cell Signaling and MicroRNA Regulation to Effect Functional Aspects of the Avian Oviduct