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MicroRNA (miRNA), a small non-coding RNA that functions as a mediator in gene silencing, plays important roles in gene regulation in various vital functions and activities. Here we show that the  miR-29  members are upregulated in  klotho -deficient [ klotho(−/−) ] mice, a senescence-model animal, and also in normal elderly ICR mice relative to wild-type littermates and young ICR mice. In addition, levels of type IV collagen, a major component of basement membranes and a putative target of  miR-29 , were lower in  klotho(−/−)  and elderly ICR mice than in wild-type littermates and young ICR mice. RNA degradation mediated by  miR-29  may participate in the suppression of type IV collagen, both  in vivo  and  in vitro . Taken together, our current findings suggest that the  miR-29  upregulated in aging may be involved in the downregulation of type IV collagen, leading to a possible weakening of the basal membrane in senescent tissues, and  miR-29  may be a useful molecular marker of senescence.

Reduction of Type IV Collagen by Upregulated miR-29 in Normal Elderly Mouse and klotho-Deficient, Senescence-Model Mouse