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IgM provides a first line of defense during microbial infections. Serum IgM levels are detected routinely in clinical practice. And IgM is a genetically complex trait. We conducted a two-stage genome-wide association study (GWAS) to identify genetic variants affecting serum IgM levels in a Chinese population of 3495, including 1999 unrelated subjects in the first stage and 1496 independent individuals in the second stage. Our data show that a common single nucleotide polymorphism (SNP), rs11552708 located in the  TNFSF13  gene was significantly associated with IgM levels ( p  = 5.00×10 −7  in first stage,  p  = 1.34×10 −3  in second stage, and  p  = 4.22×10 −9  when combined). Besides, smoking was identified to be associated with IgM levels in both stages ( P <0.05), but there was no significant interaction between smoking and the identified SNP ( P >0.05). It is suggested that  TNFSF13  may be a susceptibility gene affecting serum IgM levels in Chinese male population.

Genome-Wide Scan Identifies Variant in TNFSF13 Associated with Serum IgM in a Healthy Chinese Male Population