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Background  DNA repair genes (eg: xeroderma pigmentosum group D, XPD) may affect the capacity of encoded DNA repair enzymes to effectively remove DNA adducts or lesions, which may result in enhanced cancer risk. The association between XPD gene polymorphisms and the susceptibility of prostate cancer (PCa) was inconsistent in previous studies.    Methodology/Principal Findings  A meta-analysis based on 9 independent case-control studies involving 3165 PCa patients and 3539 healthy controls for  XPD Gln751Lys  SNP (single nucleotide polymorphism) and 2555 cases and 3182 controls for  Asn312Asp  SNP was performed to address this association. Meanwhile, odds ratio (OR) and 95% confidence intervals (CIs) were used to evaluate this relationship. Statistical analysis was performed with STATA10.0. No significant association was found between  XPD Gln751Lys  SNP and PCa risk. On the other hand, in subgroup analysis based on ethnicity, associations were observed in Asian (eg.  Asn  vs.  Asp : OR = 1.34, 95%CI = 1.16–1.55;  Asn/Asn+Asn/Asp  vs.  Asp/Asp : OR = 1.23, 95%CI = 1.07–1.42) and African (eg.  Asn  vs.  Asp : OR = 1.31, 95%CI = 1.01–1.70;  Asn/Asn  vs.  Asp/Asp : OR = 1.71, 95%CI = 1.03–7.10) populations for  Asn312Asp  SNP. Moreover, similar associations were detected in hospital-based controls studies; the frequency of  Asn/Asn  genotype in early stage of PCa men was poorly higher than those in advanced stage of PCa men (OR = 1.45, 95%CI = 1.00–2.11).    Conclusion/Significance  Our investigations demonstrate that  XPD Asn312Asp  SNP not the  Gln751Lys  SNP, might poorly increase PCa risk in Asians and Africans, moreover, this SNPs may associate with the tumor stage of PCa. Further studies based on larger sample size and gene-environment interactions should be conducted to determine the role of XPD gene polymorphisms in PCa risk.

Impact of Two Common Xeroderma Pigmentosum Group D (XPD) Gene Polymorphisms on Risk of Prostate Cancer