English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A functional relationship between chromatin structure and mRNA processing events has been suggested, however, so far only a few involved factors have been characterized. Here we show that  rsc nhp6ΔΔ  mutants, deficient for the function of the chromatin remodeling factor RSC and the chromatin architectural proteins Nhp6A/Nhp6B, accumulate intron-containing pre-mRNA at the restrictive temperature. In addition, we demonstrate that  rsc8-ts16 nhp6ΔΔ  cells contain low levels of U6 snRNA and U4/U6 di-snRNA that is further exacerbated after two hours growth at the restrictive temperature. This change in U6 snRNA and U4/U6 di-snRNA levels in  rsc8-ts16 nhp6ΔΔ  cells is indicative of splicing deficient conditions. We identify  MRN1  ( m ulti-copy suppressor of   r sc  n hp6ΔΔ ) as a growth suppressor of  rsc nhp6ΔΔ  synthetic sickness. Mrn1 is an RNA binding protein that localizes both to the nucleus and cytoplasm. Genetic interactions are observed between  2 µm-MRN1  and the splicing deficient mutants  snt309Δ ,  prp3 ,  prp4 , and  prp22 , and additional genetic analyses link  MRN1 ,  SNT309 ,  NHP6A/B ,  SWI/SNF , and  RSC  supporting the notion of a role of chromatin structure in mRNA processing.

MRN1 Implicates Chromatin Remodeling Complexes and Architectural Factors in mRNA Maturation