English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Acute myeloid leukemia patients with normal cytogenetics (CN-AML) account for almost half of AML cases. We aimed to study the frequency and relationship of a wide range of genes previously reported as mutated in AML ( ASXL1 ,  NPM1 ,  FLT3 ,  TET2 ,  IDH1 / 2 ,  RUNX1 ,  DNMT3A ,  NRAS ,  JAK2 ,  WT1 ,  CBL ,  SF3B1 ,  TP53 ,  KRAS  and  MPL ) in a series of 84 CN-AML cases. The most frequently mutated genes in primary cases were  NPM1  (60.8%) and  FLT3  (50.0%), and in secondary cases  ASXL1  (48.5%) and  TET2  (30.3%). We showed that 85% of CN-AML patients have mutations in at least one of  ASXL1 ,  NPM1 ,  FLT3 ,  TET2 ,  IDH1/2  and/or  RUNX1 . Serial samples from 19 MDS/CMML cases that progressed to AML were analyzed for  ASXL1/TET2/IDH1/2  mutations; seventeen cases presented mutations of at least one of these genes. However, there was no consistent pattern in mutation acquisition during disease progression. This report concerns the analysis of the largest number of gene mutations in CN-AML studied to date, and provides insight into the mutational profile of CN-AML.

Mutation Patterns of 16 Genes in Primary and Secondary Acute Myeloid Leukemia (AML) with Normal Cytogenetics