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Dysregulation of the complement system has been linked to pathogenesis of hypertension. However, whether genetic changes of complement factor H (CFH) and its related genes are associated with hypertension is unknown. We genotyped three SNPs in the  CFH  gene cluster that are closely linked to age-related macular degeneration, namely rs1061170 (Y402H), rs2274700 (A473A) and rs7542235 ( CFHR1–3 Δ), and tested for their associations with blood pressure and hypertension risk in a population-based cohort including 3,210 unrelated Chinese Hans (50–70 years of age) from Beijing and Shanghai. We found that rs2274700 (A473A) and rs7542235 ( CFHR1–3 Δ) were both significantly associated with diastolic blood pressure (DBP) (β = 0.632–1.431,  P ≤0.038) and systolic blood pressure (SBP) (β = 1.567–4.445,  P ≤0.008), and rs2274700 (A473A) was associated with hypertension risk (OR [95%CI]: 1.175 [1.005–1.373],  P  = 0.048). Notably, the associations of rs2274700 (A473A) with DBP ( P  = 2.1×10 −3 ), SBP ( P  = 8×10 −5 ) and hypertension risk ( P  = 7.9×10 −3 ) were significant only in the individuals with low CRP levels (<2.0 mg/l), but not in those with CRP levels ≥2.0 mg/l ( P ≥0.0807) ( P  for interaction ≤0.0467). However, no significant association between rs1061170 (Y402H) and blood pressure or hypertension risk was observed ( P ≥0.259). In conclusion, our results suggest that genetic variations in  CFH  and its related genes may contribute to hypertension risk in Chinese Hans.

Associations of CFH Polymorphisms and CFHR1-CFHR3 Deletion with Blood Pressure and Hypertension in Chinese Population