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We recently generated  rab -Gal4 lines for 25 of 29 predicted  Drosophila rab  GTPases. These lines provide tools for the expression of reporters, mutant  rab  variants or other genes, under control of the regulatory elements of individual  rab  loci. Here, we report the generation and characterization of the remaining four  rab -Gal4 lines. Based on the completed ‘ rab -Gal4 kit’ we performed a comparative analysis of the cellular and subcellular expression of all  rab  GTPases. This analysis includes the cellular expression patterns in characterized neuronal and non-neuronal cells and tissues, the subcellular localization of wild type, constitutively active and dominant negative  rab  GTPases and colocalization with known intracellular compartment markers. Our comparative analysis identifies all Rab GTPases that are expressed in the same cells and localize to the same intracellular compartments. Remarkably, similarities based on these criteria are typically not predicted by primary sequence homology. Hence, our findings provide an alternative basis to assess potential roles and redundancies based on expression in developing and adult cell types, compartment identity and subcellular localization.

Similarities of Drosophila rab GTPases Based on Expression Profiling: Completion and Analysis of the rab-Gal4 Kit