English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

CD4 + CD25 +  regulatory T cells (Tregs) do not only influence self-antigen specific immune responses, but also dampen the protective effect induced by a number of vaccines. The impact of CD4 + CD25 +  Tregs on vaccines against schistosomiasis, a neglected tropical disease that is a major public health concern, however, has not been examined. In this study, a DNA vaccine encoding a 26 kDa glutathione S-transferase of  Schistosoma japonicum  (pVAX1-Sj26GST) was constructed and its potential effects were evaluated by depleting CD25 +  cells prior to pVAX1-Sj26GST immunization. This work shows that removal of CD25 +  cells prior to immunization with the pVAX1-Sj26GST schistosomiasis DNA vaccine significantly increases the proliferation of splenocytes and IgG levels. However, CD25 +  cell-depleted mice immunized with pVAX1-Sj26GST show no improved protection against  S. japonicum . Furthermore, depletion of CD25 +  cells causes an increase in both pro-inflammatory cytokines (e.g. IFN-γ, GM-CSF and IL-4) and an anti-inflammatory cytokine (e.g. IL-10), with CD4 + CD25 -  T cells being one of the major sources of both IFN-γ and IL-10. These findings indicate that partial CD25 +  cell depletion fails to enhance the effectiveness of the schistosome vaccine, possibly due to IL-10 production by CD4 + CD25 -  T cells, or other cell types, after CD25 +  cell depletion during vaccination.

Partial Regulatory T Cell Depletion Prior to Schistosomiasis Vaccination Does Not Enhance the Protection