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Objective  To evaluate associations between quality of life (QOL) and use of ginseng and  Ganoderma lucidum  ( G. lucidum ) among breast cancer survivors.    Methods  Included in this study were 4,149 women with breast cancer who participated in the Shanghai Breast Cancer Survival Study. Ginseng use was assessed at 6-, 18-, and 36-month post-diagnosis surveys;  G. lucidum  use was assessed at the 6- and 36-month surveys. QOL was evaluated at the 6- and 36-month surveys. Multiple linear regression models were used to examine associations between ginseng and  G.lucidum  use and QOL assessed at the 36-month survey, with adjustment for potential confounders and baseline QOL.    Results  At 6 months post-diagnosis, 14.2% of participants reported regular use of ginseng and 58.8% reported use of  G. lucidum . We found no significant associations between ginseng use at 6, 18, and 36 months post-diagnosis and participants’ total QOL score or individual scores for psychological, physical, or social well-being. Post-diagnosis  G. lucidum  use was positively associated with social well-being (adjusted mean difference: 1.26; 95% CI: 0.66, 1.86), but was inversely associated with physical well-being (adjusted mean difference: −1.16; 95% CI: −1.86, −0.47) with a dose-response pattern observed for cumulative number of times of use ( P  for trend <0.001 for both).    Conclusion  We found no evidence that post-diagnosis ginseng use improved the QOL of breast cancer survivors. Post-diagnosis  G. lucidum  use was associated with better social well-being scores, but poorer physical well-being scores.

Ginseng and Ganoderma lucidum Use after Breast Cancer Diagnosis and Quality of Life: A Report from the Shanghai Breast Cancer Survival Study