English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Bacterial infections trigger the expression of type I and II interferon genes but little is known about their effect on type III interferon (IFN-λ) genes, whose products play important roles in epithelial innate immunity against viruses. Here, we studied the expression of IFN-λ genes in cultured human epithelial cells infected with different pathogenic bacteria and in the mouse placenta infected with  Listeria monocytogenes . We first showed that in intestinal LoVo cells, induction of IFN-λ genes by  L. monocytogenes  required bacterial entry and increased further during the bacterial intracellular phase of infection. Other Gram-positive bacteria,  Staphylococcus aureus, Staphylococcus epidermidis  and  Enterococcus faecalis,  also induced IFN-λ genes when internalized by LoVo cells. In contrast, Gram-negative bacteria  Salmonella enterica  serovar Typhimurium,  Shigella flexneri  and  Chlamydia trachomatis  did not substantially induce IFN-λ. We also found that IFN-λ genes were up-regulated in A549 lung epithelial cells infected with  Mycobacterium tuberculosis  and in HepG2 hepatocytes and BeWo trophoblastic cells infected with  L. monocytogenes . In a humanized mouse line permissive to fetoplacental listeriosis,  IFN-λ2/λ3  mRNA levels were enhanced in placentas infected with  L. monocytogenes . In addition, the feto-placental tissue was responsive to IFN-λ2. Together, these results suggest that IFN-λ may be an important modulator of the immune response to Gram-positive intracellular bacteria in epithelial tissues.

Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta