Open AccessDefining and Detecting Crossover-Interference Mutants in Yeast
Author(s) -
Frank Stahl
Publication year - 2012
Publication title -
plos one
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.99
H-Index - 332
ISSN - 1932-6203
DOI - 10.1371/journal.pone.0038476
Subject(s) - creatures , interference (communication) , saccharomyces cerevisiae , crossover , tetrad , mutant , genetics , rna interference , biology , meiosis , computational biology , computer science , yeast , gene , telecommunications , artificial intelligence , paleontology , channel (broadcasting) , rna , natural (archaeology)
The analysis of crossover interference in many creatures is complicated by the presence of two kinds of crossovers, interfering and noninterfering. In such creatures, the values of the traditional indicators of interference are subject not only to the strength of interference but also to the relative frequencies of crossing over contributed by the two kinds. We formalize the relationship among these variables and illustrate the possibilities and limitations of classical interference analysis with meiotic tetrad data from wild-type Saccharomyces cerevisiae and from mlh1 and ndj1 mutants.
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