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Background  To investigate the association between  XPD  Asp312Asn polymorphism and head and neck cancer risk through this meta-analysis.    Methods  We performed a meta-analysis of 9 published case-control studies including 2,670 patients with head and neck cancer and 4,452 controls. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between  XPD  Asp312Asn polymorphism and head and neck cancer risk.    Results  Overall, no significant association between  XPD  Asp312Asn polymorphism and head and neck cancer risk was found in this meta-analysis (Asn/Asn vs. Asp/Asp: OR = 0.95, 95%CI = 0.80–1.13,  P  = 0.550,  P   heterogeneity  = 0.126; Asp/Asn vs. Asp/Asp: OR = 1.11, 95%CI = 0.99–1.24,  P  = 0.065,  P   heterogeneity  = 0.663; Asn/Asn+Asp/Asn vs. Asp/Asp: OR = 1.07, 95%CI = 0.97–1.19,  P  = 0.189,  P   heterogeneity  = 0.627; Asn/Asn vs. Asp/Asp+Asp/Asn: OR = 0.87, 95%CI = 0.68–1.10,  P  = 0.243,  P   heterogeneity  = 0.089). In the subgroup analysis by HWE, ethnicity, and study design, there was still no significant association detected in all genetic models.    Conclusions  This meta-analysis demonstrates that  XPD  Asp312Asn polymorphism may not be a risk factor for developing head and neck cancer.

Associations between XPD Asp312Asn Polymorphism and Risk of Head and Neck Cancer: A Meta-Analysis Based on 7,122 Subjects