English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

During mammalian development the cerebral metabolic rate correlatesqualitatively with synaptogenesis, and both often exhibit bimodal temporalprofiles. Despite these non-monotonic dependencies, it is found based onempirical data for different mammals that regional metabolic rate per synapseis approximately conserved from birth to adulthood for a given species (with aslight deviation from this constancy for human visual and temporal corticesduring adolescence). A typical synapse uses about $(7\pm 2)\cdot 10^{3}$glucose molecules per second in primate cerebral cortex, and about 5 times ofthat amount in cat and rat visual cortices. A theoretical model for brainmetabolic expenditure is used to estimate synaptic signaling and neural spikingactivity during development. It is found that synaptic efficacy is generallyinversely correlated with average firing rate, and additionally, synapsesconsume a bulk of metabolic energy, roughly $50-90 %$ during most of thedevelopmental process (except human temporal cortex $ < 50%$). Overall, theseresults suggest a tight regulation of brain electrical and chemical activitiesduring the formation and consolidation of neural connections. This presumablyreflects strong energetic constraints on brain development.

Approximate invariance of metabolic energy per synapse during development in mammalian brains