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Summary  The main objective was to evaluate the association between SNPs and haplotypes of the  FABP1-4  genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated.    Methods  1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in both studies. Fifteen SNPs previously associated with metabolic traits or with potential influence in the gene expression within the  FABP1-4  genes were genotyped with SNPlex and tested. Age, sex and BMI were used as covariates in the logistic regression model.    Results  One polymorphism ( rs2197076 ) and two haplotypes of the  FABP-1  showed a strong association with the risk of DM2 in the original population. This association was further confirmed in the second population as well as in the pooled sample. None of the other analyzed variants in  FABP2 ,  FABP3  and  FABP4  genes were associated. There was not a formal interaction between  rs2197076  and fat intake. A significant association between the  rs2197076  and the haplotypes of the  FABP1  and HOMA-IR was also present in the replication population.    Conclusions  The study supports the role of common variants of the  FABP-1  gene in the development of type 2 diabetes in Caucasians.

Common Variants of the Liver Fatty Acid Binding Protein Gene Influence the Risk of Type 2 Diabetes and Insulin Resistance in Spanish Population